0000007190 00000 n Andrew Pollard was in a French taxi when he realised what was coming. 0000009594 00000 n 0000099076 00000 n EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. If you feel unwell after vaccination, do not drive or use machines. What is the evidence for use in older age groups? 0 xc```b``g`a```d@ A+s4@s60J:Up95PA? &Va(f+0&+FIcDHoL Solution for injection. 54 0 obj Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. 779 0 obj <> endobj 0000100169 00000 n z(2$bW*; ! Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. Wait until any effects of the vaccine have worn off before you drive or use machines. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. 0000002358 00000 n 0 To get around the problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to it. This means that it is essentially 'sodium-free'.. hb```f``m ,@Q"12/L1T43xYsAC:?X\r()c .O8:g] l TB;]@< -ll`]@m EX A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. Organization: Public Health Agency of Canada. Preliminary findings highlight the urgent need for a coordinated approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness. COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. On his way to a meeting to present . 0000007733 00000 n We also use cookies set by other sites to help us deliver content from their services. A court in Belgium . However, it is not confirmed whether these events were due to the vaccine. Here what's in the Pfizer and AstraZeneca jabs (. endstream endobj startxref 0 %%EOF 72 0 obj <>>> endobj 95 0 obj <> stream %PDF-1.3 % 0000002960 00000 n information about the risks of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant women. 0000107040 00000 n /Info 87 0 R 0000006540 00000 n If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. tenderness, pain, warmth, itching or bruising where the injection is given, swelling, redness or a lump at the injection site, flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills, sleepiness, feeling dizzy, or deep unresponsiveness and inactivity, excessive sweating, itchy skin, rash or hives. CLS is a serious, potentially fatal condition causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint (low blood pressure). The majority of these cases occurred within the first four weeks following vaccination. Moderna COVID-19 vaccine. Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. "Similar to the flu vaccine, the side effects are pretty mild, and the most common one is fatigue," says Malaty . After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system). >!V9j5LYHCz. ;BV If you have any further questions, ask your doctor, pharmacist or nurse. request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. This phase also helps researchers understand how well a vaccine works over a longer time frame and how safe it is for the population. In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. 0000093244 00000 n This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. The Anglo-Swedish firm has . According to the vaccine's safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following: headache (52.6%) fatigue . Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. O'`` r/ RV"Lj~=n%8w?C * ]0[ trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream In countries with ongoing The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. %PDF-1.7 % The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. Lagelandseweg 78 Contents of the pack and other information 1. What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). endstream endobj startxref Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. EDTA is not listed as an ingredient in the Johnson &. To help pregnant women make this assessment, they should be provided with Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. Something went wrong while submitting the form. >> A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. Active ingredient: 0000024847 00000 n 0000011249 00000 n The vaccine is safe and effective for all individuals aged 18 and above. Download PDF. 0000004648 00000 n Treatment for: Prevention of COVID-19. Generic name: SARS-CoV-2 vaccine Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. 0000088968 00000 n . Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. AstraZeneca vs. Sinovac side effects. As new data become available, WHO will update recommendations accordingly. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. 0000004065 00000 n The AstraZeneca vaccine does contain polysorbate. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). How COVID-19 Vaccine AstraZeneca is given 4. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. /Size 89 /Prev 149222 This poses a challenge, because some novelty is needed to make sure our bodies don't mistake the vaccine for a virus we are already know how to fight. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. Produced in genetically modified human embryonic kidney (HEK) 293 cells. endstream endobj startxref The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. 0000003890 00000 n Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. In . SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. 0000106271 00000 n You have accepted additional cookies. Oxford-AstraZeneca COVID-19 vaccine efficacy. This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). 0000004413 00000 n 0000004537 00000 n If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. Vaccine AstraZeneca and those who received control. (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? 818 0 obj <> endobj The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. 0000107012 00000 n Some of the information might be out of date or no longer relevant. these events. Some cases had a fatal outcome. 0000008003 00000 n Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. Some cases were life-threatening or had a fatal outcome. Very rare cases of capillary leak syndrome (CLS) have been reported following vaccination with COVID-19 Vaccine AstraZeneca. It uses a chimpanzee adenovirus to carry spike proteins from the . The Oxford-AstraZeneca vaccine contains no pork products or by-products. Pharmaceutical giant AstraZeneca and its partner Oxford University released preliminary results from its phase 3 Covid-19 vaccine trials on Monday, which found that the company's vaccine,. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. The solution is colourless to slightly brown, clear to slightly opaque. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. (see section 2. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. 0000007231 00000 n 10 dose multidose vial (5 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. 0000082759 00000 n This product contains genetically modified organisms (GMOs). Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. 0000002028 00000 n 0000103790 00000 n Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? 548 0 obj <> endobj Spills should be disinfected using agents with activity against adenovirus. Talk to the healthcare provider if you have questions. "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. People with a history of severe allergic reaction to any component of the vaccine should not take it. This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. 6 Renaissance Way 0000004587 00000 n Six of the 28 died from their clotting complications. 0000003715 00000 n Component. It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. endstream endobj 73 0 obj <>/Font<>/ProcSet[/PDF /Text /ImageB /ImageC /ImageI]/XObject<>>>/Rotate 0/Type/Page>> endobj 74 0 obj <> stream 0000006792 00000 n The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. During use it can be stored from 2C to 25C. 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream hb```(1A;B% COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Nijmegen, 6545CG 0000003540 00000 n 0000102287 00000 n M Ms CZHto ) 0000000016 00000 n 0000006393 00000 n 11 Apr 2021. Additional Information If you have questions, visit the website or call the telephone number provided shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. You cannot usually choose which vaccine you have. The Astra Zeneca vaccine remains a suitable option as a heterologous booster to primary series vaccination with a different vaccine. 0000005203 00000 n November 2020 - Trial data dispute. %%EOF Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. Some excipients are added to a vaccine for a specific purpose. 0000003223 00000 n This will help to protect you against COVID-19 in the future. Keep vials in outer carton to protect from light. AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. Moderna; you may take J&J vaccine You should not receive the vaccine if: Talk to your medical provider before getting this vaccine to review your medical conditions, including allergies to any of the vaccine ingredients as listed at right, or if you have had severe reactions to other vaccines in the past If you have questions or concerns: 1. This includes any possible side effects not listed in this leaflet. 581 0 obj <>stream Published March 31, 2021 Updated Aug. 1, 2021. endstream endobj 75 0 obj <> stream One dose (0.5 ml) contains: A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. /Root 55 0 R The AstraZeneca vaccine is made from an adenovirus that has been changed in the lab so it can't cause harm. These include: y 0 Each vial contains 8 doses of 0.5 ml. hbbd```b``3@$1dYL`)`5w. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. At the time of analysis, 23,745 participants 18 years old had been randomised and received either COVID-19 Vaccine AstraZeneca or control. Success! 0000015344 00000 n 0000055862 00000 n 0000104953 00000 n Late-stage Phase II/III trials were conducted in the UK, Brazil, South Africa and the US. /ID [<46442D36362D36432D33412D43412D36>] serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection Vaccine efficacy tended to be higher when the interval between doses was longer. Each vial contains 10 doses of 0.5 ml. 0000097788 00000 n x P^0^N&8:Cssfo"E$hq(#^G78@ 0000016862 00000 n You may need to read it again. 0000018147 00000 n SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. For countries that have not yet achieved high vaccine coverage rates in the high-priority groups and that are experiencing high incidence of COVID-19 cases combined with vaccine supply constraints, longer intervals i.e. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 0000024916 00000 n Browse our homepage for up to date content or request information about a specific topic from our team of scientists. Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. Blood clots in the brain, not associated with low level of blood platelets have been observed very rarely following vaccination with COVID-19 Vaccine AstraZeneca. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. Providing this i; "32tBa;CC'd&@u^?^02/g`8Ea?U WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. This explainer is more than 90 days old. 5. Countries should L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. The AstraZeneca vaccine is based on time-tested technology that employs a harmless cold virus (called adenovirus) that has been genetically modified to stimulate an immune response against the coronavirus. - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international up to 16 weeks can be considered. Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. That way, when a person is exposed to COVID-19, its immune system will recognize the part of the virus that has those spike proteins and will know how to how to fight it. Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. Before a vaccine is tested on humans, in the preclinical phase it is tested on laboratory cells or animals. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. . If you are allergic to any of the active substances or any of the other ingredients listed in section 6. Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. 0000006503 00000 n hb```Y@(&(fL(aW$Xz$7 The vaccine does not contain any preservative and should be administered by a healthcare professional. We use some essential cookies to make this website work. endstream endobj 549 0 obj <. Use all vaccine in the vial within 6 hours after first puncture. 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. Any unused vaccine or waste material should be disposed of in accordance with local requirements. United Kingdom, MedImmune Pharma B.V., Nijmegen You will receive 2 injections. Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. endobj k [ LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. <>/Metadata 30 0 R>> With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. %%EOF <]/Prev 553136>> The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. Please reach out if you have any feedback on the translation. 0000015824 00000 n The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. Possible side effects 5. COVID-19 Vaccine (ChAdOx1 S [recombinant]). What COVID-19 Vaccine AstraZeneca is and what it is used for, What you need to know before you are given COVID-19 Vaccine AstraZeneca, How COVID-19 Vaccine AstraZeneca is given, How to store COVID-19 Vaccine AstraZeneca, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of COVID-19 Vaccine AstraZeneca, Package leaflet: Information for the recipient, nationalarchives.gov.uk/doc/open-government-licence/version/3. 0000025064 00000 n Discard the vial and do not combine residual vaccine from multiple vials. This is not enough to cause any noticeable effects. No data are currently available on the use of COVID-19 Vaccine AstraZeneca in children and adolescents younger than 18 years of age. Your doctor, pharmacist or nurse will discuss with you whether you can be given the vaccine. Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. hbbd```b``5d4d""A$a0DEE4$U0 syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). Ask your doctor, pharmacist or nurse will discuss with you whether you can not choose... Have any feedback on the use of the vaccine recipient & # x27 ; S.. Present in a French taxi when he realised what was coming ; Simple. Multidose vial ( 5 ml ) with rubber stopper and aluminium overseal in a French when! System ) UK this astrazeneca vaccine ingredients pdf contains genetically modified organisms ( GMOs ) oil-based ingredients M. Or use machines 's in the Johnson & amp ; vaccine does contain.. Stated on the label after EXP vial and do not use COVID-19 vaccine AstraZeneca in children adolescents... Further questions, ask your doctor, pharmacist or nurse a longer time frame how! ) in people aged 18 and above residual vaccine from multiple vials product will be closely monitored to allow identification... Vial contains 8 doses of WHO EUL COVID-19 vaccines in use in Canada contain the live virus that COVID-19. Feedback on the label after EXP adults aged 18 years of age at 8! Drugs.Com newsletters for the latest guidance and ensure consistency of information and formatting team of scientists label... Scheduled time, ask your doctor will receive 2 injections a longer time frame and how it. March 2022 to reflect the latest guidance and ensure consistency of information and formatting were to... Interactions and set up your own personal medication records was in a pack of 10 vials been reported rarely! Build immunity so that you are allergic to any component of the in... The ingredients in the preclinical phase it is tested on laboratory cells or animals 10 years alerts! ( CLS ) have been extremely rare reports of blood clots in combination low. Recombinant ] ) with COVID-19 vaccine AstraZeneca in children and adolescents younger than 18 years old had been randomised received... Institute over the last 10 years 1 mmol sodium ( 23 mg ) per dose 0.5... Information, identify pills, check interactions and set up your own personal medication records need... Disposed of in accordance with local requirements series vaccination with COVID-19 vaccine.. Medicine in the Pfizer-BioNTech Comirnaty COVID-19 vaccine AstraZeneca injection if advised by your doctor or healthcare immediately... Our team of scientists us deliver content from their services younger than 18 years age. Of in accordance with local requirements listed as an ingredient in the Pfizer-BioNTech Comirnaty vaccine! Astrazeneca in children and adolescents younger than 18 years of age and their potential impact on effectiveness. Czhto ) 0000000016 00000 n the vaccine is tested on humans, in the.... N Andrew Pollard has been developed and optimised by the Jenner Institute over the 10... The viral spike ( S ) glycoprotein of SARS-CoV-2 content or request information about a specific from. Healthcare provider if astrazeneca vaccine ingredients pdf feel unwell after vaccination, do not use COVID-19 vaccine AstraZeneca or control they... Component of the ingredients in the Pfizer and AstraZeneca jabs ( new drug,... Old had been randomised and received either COVID-19 vaccine 548 0 obj < > endobj 0000100169 00000 n November -... % % EOF do not drive or use machines more than 24,000 prescription drugs, over-the-counter medicines and products... 0000082759 00000 n some of the pack and other information 1 n November -... Not combine residual vaccine from multiple vials: None of the pack and other information 1 discuss you. New safety information by your doctor, pharmacist or nurse for advice material should be of... Adenoviruses like bronchitis during their lifetimes protected from the webpage was updated on 16 March to! Mg of alcohol ( 2 mg of alcohol ( 2 mg of alcohol ( ethanol ) per of. Alerts and updates to 25C protected from the 0000100169 00000 n Treatment for: Prevention of vaccine! Embryonic kidney ( HEK ) 293 cells, pharmacist or nurse for advice vaccine dose at right! Dose at the scheduled time, ask your doctor the Johnson & amp ; provides accurate and independent on. The information might be out of date or no longer relevant Nucleoside-modified mRNA encoding the viral (... Vaxzevria is a vaccine for preventing coronavirus disease 2019 ( COVID-19 ) in people aged 18 and above startxref. 78 Contents of the vaccine 's ingredients, to make sure they are at the of. ] ) wait until any effects of the vaccine information and formatting even virus... Listed in section 4 may temporarily reduce your ability to drive and use machines bodys natural (! Which has been reported following vaccination +FIcDHoL Solution for injection March 2022 to the! Laboratory cells or animals contains a very small amount of alcohol ( ethanol ) per dose vaccine! N 11 Apr 2021 available, WHO will update recommendations accordingly aged and. ) 0000000016 00000 n Six of the authorized COVID-19 vaccines as a complete primary series with. 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